Semaglutide is a single receptor agonist. Semaglutide works by mimicking the activity of GLP-1 and can help reduce your appetite and lower the amount of calories you consume. Semaglutide also slows down how fast food moves from your stomach to your intestines, which can help you feel full for longer.  Though slightly less effective than tirzepatide and retatrutide, semaglutide is more cost effective

Tirzepatide is a dual receptor agonist, working on both the GLP-1 and GIP hormones that are naturally secreted by the intestine after a meal, which prompts insulin secretion. It also reduces appetite by slowing down the time it takes the stomach to empty and interacting with areas in the brain harboring GLP-1 receptors to signal satiety.  Studies have shown that patients taking tirzepatide do experience more weight loss than those on semaglutide.